You have to pay attention now to exactly what gets Lethal Hits as well.
Tempestus Scions Command Squad is the only unit that can formally give orders and has the regiment keyword. Kasrkin can still do pseudo orders with their rule.
The Platoon Command Squad and Cadian Command Squad don't have regiment, so they don't get Lethal Hits, and no character can get the detachment rule to gain lethal hits, except for the Tempestor Prime.
Catachans can still get lethal hits against everything in Melee with Straken.
Abhumans all lose any chance at Lethal Hits.
It might now be worth running a 20 man squad of Cadians with Creed and a Castellan to get Sustained Hits 1 and the ability to receive 2 sets of orders. You can get a lot of shots with lethal hits at 3+ with Sustained Hits 1 and FRFSRF.
The Leman Russ Punisher still has Devastating Wounds with the Punisher Gatling Cannon against infantry. Now it has a lot of Lethal Hits against vehicles. It's a really weird use case. Given that you don't have to shoot all of the guns at one unit, it might be turned into a takes all comers tank using a lascannon and mulitmeltas against big targets while using the punisher cannon against infantry.